Version 5.4
Homo sapiens Protein: SOX14
Summary
InnateDB Protein IDBP-58066.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SOX14
Protein Name SRY (sex determining region Y)-box 14
Synonyms SOX28;
Species Homo sapiens
Ensembl Protein ENSP00000305343
InnateDB Gene IDBG-58064 (SOX14)
Protein Structure
UniProt Annotation
Function Acts as a negative regulator of transcription. {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00267}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003682 chromatin binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007399 nervous system development
GO:0007601 visual perception
GO:0009649 entrainment of circadian clock
GO:0045892 negative regulation of transcription, DNA-templated
GO:2001222 regulation of neuron migration
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
GO:0044798 nuclear transcription factor complex
Protein Structure and Domains
PDB ID
InterPro IPR009071 High mobility group box domain
IPR022097 Transcription factor SOX
PFAM PF00505
PF09011
PF12336
PRINTS
PIRSF
SMART SM00398
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95416
PhosphoSite PhosphoSite-O95416
TrEMBL
UniProt Splice Variant
Entrez Gene 8403
UniGene Hs.248184
RefSeq NP_004180
HUGO HGNC:11193
OMIM 604747
CCDS CCDS3094
HPRD 16067
IMGT
EMBL AF032451 AF107043 AF193436 AJ006230 AK314127 BC106729 BC106730 CH471052
GenPept AAC94971 AAC95380 AAF76294 AAI06730 AAI06731 BAG36817 CAB43111 EAW79097

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca