Version 5.4
Homo sapiens Gene: SOX14
Summary
InnateDB Gene IDBG-58064.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SOX14
Gene Name SRY (sex determining region Y)-box 14
Synonyms SOX28
Species Homo sapiens
Ensembl Gene ENSG00000168875
Encoded Proteins
IDBP-58066
SRY (sex determining region Y)-box 14
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. Mutations in this gene are suggested to be responsible for the limb defects associated with blepharophimosis, ptosis, epicanthus inversus syndrome (BPES) and Mobius syndrome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:137764284-137766338
Strand Forward strand
Band q22.3
Transcripts
ENST00000306087 ENSP00000305343
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003682 chromatin binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007399 nervous system development
GO:0007601 visual perception
GO:0009649 entrainment of circadian clock
GO:0045892 negative regulation of transcription, DNA-templated
GO:2001222 regulation of neuron migration
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
GO:0044798 nuclear transcription factor complex
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000053747
View Gene Order
Cross-References
SwissProt O95416
TrEMBL
UniProt Splice Variant
Entrez Gene 8403
UniGene Hs.248184
RefSeq NM_004189
HUGO HGNC:11193
OMIM 604747
CCDS CCDS3094
HPRD
IMGT
EMBL AF032451 AF107043 AF193436 AJ006230 AK314127 BC106729 BC106730 CH471052
GenPept AAC94971 AAC95380 AAF76294 AAI06730 AAI06731 BAG36817 CAB43111 EAW79097
RNA Seq Atlas 8403

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca