InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CLDN18

Summary

InnateDB Protein

IDBP-58077.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLDN18

Protein Name

claudin 18

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000183605

InnateDB Gene

IDBG-58073 (CLDN18)

Protein Structure

UniProt Annotation

Function

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. {ECO:0000250}.

Subcellular Localization

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Concentrated at the cell-cell borders of epithelial cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0042802	identical protein binding

Biological Process

GO:0016338	calcium-independent cell-cell adhesion
GO:0034329	cell junction assembly
GO:0045216	cell-cell junction organization
GO:0070830	tight junction assembly