Version 5.4
Homo sapiens Gene: CLDN18
Summary
InnateDB Gene IDBG-58073.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLDN18
Gene Name claudin 18
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000066405
Encoded Proteins
IDBP-58075
claudin 18
IDBP-58077
claudin 18
IDBP-477981
claudin 18
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:137998735-138033655
Strand Forward strand
Band q22.3
Transcripts
ENST00000343735 ENSP00000340939
ENST00000183605 ENSP00000183605
ENST00000479660 ENSP00000419732
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0042802 identical protein binding
Biological Process
GO:0016338 calcium-independent cell-cell adhesion
GO:0034329 cell junction assembly
GO:0045216 cell-cell junction organization
GO:0070830 tight junction assembly
Cellular Component
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032473
View Gene Order
ENSBTAG00000014589
Not yet available
Pathways
NETPATH
REACTOME
REACT_19373
Tight junction interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
REACT_19331
Cell-cell junction organization pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04530
Tight junction pathway
hsa05160
Hepatitis C pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.619261 Hs.655324 Hs.671976
RefSeq NM_001002026 NM_016369
HUGO
OMIM
CCDS CCDS3095 CCDS33862
HPRD 13066
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca