InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TACR1

Summary

InnateDB Protein

IDBP-58134.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TACR1

Protein Name

tachykinin receptor 1

Synonyms

NK1R; NKIR; SPR; TAC1R;

Species

Homo sapiens

Ensembl Protein

ENSP00000303522

InnateDB Gene

IDBG-58132 (TACR1)

Protein Structure

UniProt Annotation

Function

This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004995	tachykinin receptor activity
GO:0005515	protein binding
GO:0016496	substance P receptor activity

Biological Process

GO:0002118	aggressive behavior
GO:0002526	acute inflammatory response
GO:0002687	positive regulation of leukocyte migration
GO:0003051	angiotensin-mediated drinking behavior
GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007217	tachykinin receptor signaling pathway
GO:0007611	learning or memory
GO:0007616	long-term memory
GO:0008217	regulation of blood pressure
GO:0008306	associative learning
GO:0009408	response to heat
GO:0009582	detection of abiotic stimulus
GO:0009725	response to hormone
GO:0010193	response to ozone
GO:0010634	positive regulation of epithelial cell migration
GO:0010996	response to auditory stimulus
GO:0014070	response to organic cyclic compound
GO:0014910	regulation of smooth muscle cell migration
GO:0032224	positive regulation of synaptic transmission, cholinergic
GO:0032230	positive regulation of synaptic transmission, GABAergic
GO:0032355	response to estradiol
GO:0032570	response to progesterone
GO:0035094	response to nicotine
GO:0035106	operant conditioning
GO:0035815	positive regulation of renal sodium excretion
GO:0042713	sperm ejaculation
GO:0042755	eating behavior
GO:0043117	positive regulation of vascular permeability
GO:0043278	response to morphine
GO:0045471	response to ethanol
GO:0045760	positive regulation of action potential
GO:0045777	positive regulation of blood pressure
GO:0045778	positive regulation of ossification
GO:0045907	positive regulation of vasoconstriction
GO:0046878	positive regulation of saliva secretion
GO:0046887	positive regulation of hormone secretion
GO:0048265	response to pain
GO:0048266	behavioral response to pain
GO:0048660	regulation of smooth muscle cell proliferation
GO:0050671	positive regulation of lymphocyte proliferation
GO:0050679	positive regulation of epithelial cell proliferation
GO:0051496	positive regulation of stress fiber assembly
GO:0051602	response to electrical stimulus
GO:0060083	smooth muscle contraction involved in micturition
GO:0070474	positive regulation of uterine smooth muscle contraction

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0030425	dendrite
GO:0044297	cell body
GO:0071944	cell periphery

Protein Structure and Domains

PDB ID

InterPro

IPR000046 Neurokinin NK1 receptor
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000611 Neuropeptide Y receptor family
IPR001013 Neurokinin NK3 receptor
IPR001681 Neurokinin receptor
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR01024
PR00237
PR01012
PR01026
PR00244

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P25103