Version 5.4
Homo sapiens Protein: ECI2
Summary
InnateDB Protein IDBP-58296.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ECI2
Protein Name enoyl-CoA delta isomerase 2
Synonyms ACBD2; dJ1013A10.3; DRS-1; DRS1; HCA88; PECI;
Species Homo sapiens
Ensembl Protein ENSP00000369468
InnateDB Gene IDBG-58292 (ECI2)
Protein Structure
UniProt Annotation
Function Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates (By similarity). {ECO:0000250}.
Subcellular Localization Isoform 1: Mitochondrion {ECO:0000250}.Isoform 2: Peroxisome matrix.
Disease Associations
Tissue Specificity Abundant in heart, skeletal muscle and liver. Expressed in CD34(+) T-cells and CD34(+) bone marrow cells. {ECO:0000269PubMed:15217832}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 15 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000062 fatty-acyl-CoA binding
GO:0003824 catalytic activity
GO:0004165 dodecenoyl-CoA delta-isomerase activity
GO:0005102 receptor binding
Biological Process
GO:0008152 metabolic process
GO:0009062 fatty acid catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005782 peroxisomal matrix
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro IPR000582 Acyl-CoA-binding protein, ACBP
IPR001753 Crotonase superfamily
IPR029045 ClpP/crotonase-like domain
PFAM PF00887
PF00378
PRINTS PR00689
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75521
PhosphoSite PhosphoSite-O75521
TrEMBL C9J000
UniProt Splice Variant
Entrez Gene 10455
UniGene Hs.15250
RefSeq NP_001159482
HUGO HGNC:14601
OMIM 608024
CCDS CCDS4490
HPRD 16269
IMGT
EMBL AF069301 AF153612 AF244138 AK075108 AK297049 AL033383 AL136642 BC002668 BC016781 BC017474 BC033841 BC034702
GenPept AAC19317 AAD34173 AAF66247 AAH02668 AAH16781 AAH17474 AAH33841 AAH34702 BAG52068 BAG59575 CAB66577 CAI42125 CAI42127

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca