Version 5.4
Homo sapiens Gene: ECI2
Summary
InnateDB Gene IDBG-58292.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ECI2
Gene Name enoyl-CoA delta isomerase 2
Synonyms ACBD2; dJ1013A10.3; DRS-1; DRS1; HCA88; PECI
Species Homo sapiens
Ensembl Gene ENSG00000198721
Encoded Proteins
IDBP-58294
enoyl-CoA delta isomerase 2
IDBP-58296
enoyl-CoA delta isomerase 2
IDBP-58298
enoyl-CoA delta isomerase 2
IDBP-58302
enoyl-CoA delta isomerase 2
IDBP-481276
enoyl-CoA delta isomerase 2
IDBP-474501
enoyl-CoA delta isomerase 2
IDBP-478691
enoyl-CoA delta isomerase 2
IDBP-480376
enoyl-CoA delta isomerase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the hydratase/isomerase superfamily. The protein encoded is a key mitochondrial enzyme involved in beta-oxidation of unsaturated fatty acids. It catalyzes the transformation of 3-cis and 3-trans-enoyl-CoA esters arising during the stepwise degradation of cis-, mono-, and polyunsaturated fatty acids to the 2-trans-enoyl-CoA intermediates. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:4115689-4135597
Strand Reverse strand
Band p25.2
Transcripts
ENST00000380118 ENSP00000369461
ENST00000380125 ENSP00000369468
ENST00000380120 ENSP00000369463
ENST00000361538 ENSP00000354737
ENST00000496241 ENSP00000417170
ENST00000464057
ENST00000478266 ENSP00000417803
ENST00000465828 ENSP00000420309
ENST00000464583
ENST00000495548 ENSP00000417459
ENST00000489086
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 15 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000062 fatty-acyl-CoA binding
GO:0003824 catalytic activity
GO:0004165 dodecenoyl-CoA delta-isomerase activity
GO:0005102 receptor binding
Biological Process
GO:0008152 metabolic process
GO:0009062 fatty acid catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005782 peroxisomal matrix
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021417
View Gene Order
ENSBTAG00000015178
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00071
Fatty acid degradation pathway
hsa04146
Peroxisome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1LLU7
UniProt Splice Variant
Entrez Gene 10455
UniGene Hs.15250
RefSeq NM_001166010 NM_006117 NM_206836
HUGO HGNC:14601
OMIM 608024
CCDS CCDS43420 CCDS4490
HPRD 16269
IMGT
EMBL AL033383
GenPept
RNA Seq Atlas 10455

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca