InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CATSPER1

Summary

InnateDB Protein

IDBP-58305.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CATSPER1

Protein Name

cation channel, sperm associated 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000309052

InnateDB Gene

IDBG-58303 (CATSPER1)

Protein Structure

UniProt Annotation

Function

Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH. {ECO:0000269PubMed:21412338, ECO:0000269PubMed:21412339}.

Subcellular Localization

Cell projection, cilium, flagellum membrane {ECO:0000269PubMed:16625279}; Multi-pass membrane protein {ECO:0000269PubMed:16625279}. Note=Specifically located in the principal piece of sperm tail.

Disease Associations

Spermatogenic failure 7 (SPGF7) [MIM:612997]: An infertility disorder characterized by non-motile sperm or sperm motility below the normal threshold, low sperm count, increased abnormally structured spermatozoa, and reduced semen volume. {ECO:0000269PubMed:19344877}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Testis-specific. {ECO:0000269PubMed:11595941, ECO:0000269PubMed:16625279, ECO:0000269PubMed:17347248}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005227	calcium activated cation channel activity
GO:0005245	voltage-gated calcium channel activity
GO:0005515	protein binding

Biological Process

GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0007338	single fertilization
GO:0007342	fusion of sperm to egg plasma membrane
GO:0030154	cell differentiation
GO:0030317	sperm motility
GO:0032504	multicellular organism reproduction
GO:0034765	regulation of ion transmembrane transport
GO:0035036	sperm-egg recognition
GO:0051924	regulation of calcium ion transport
GO:0055085	transmembrane transport
GO:0060296	regulation of cilium beat frequency involved in ciliary motility
GO:0070509	calcium ion import
GO:0086010	membrane depolarization during action potential