Homo sapiens Gene: CATSPER1
Summary
InnateDB Gene IDBG-58303.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CATSPER1
Gene Name cation channel, sperm associated 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000175294
Encoded Proteins
cation channel, sperm associated 1
Protein Structure
Entrez Gene
Summary Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:66016752-66026517
Strand Reverse strand
Band q13.1
Transcripts
ENST00000312106 ENSP00000309052
ENST00000529244
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005227 calcium activated cation channel activity
GO:0005245 voltage-gated calcium channel activity
GO:0005515 protein binding
Biological Process
GO:0006811 ion transport
GO:0006816 calcium ion transport
GO:0007275 multicellular organismal development
GO:0007283 spermatogenesis
GO:0007338 single fertilization
GO:0007342 fusion of sperm to egg plasma membrane
GO:0030154 cell differentiation
GO:0030317 sperm motility
GO:0032504 multicellular organism reproduction
GO:0034765 regulation of ion transmembrane transport
GO:0035036 sperm-egg recognition
GO:0051924 regulation of calcium ion transport
GO:0055085 transmembrane transport
GO:0060296 regulation of cilium beat frequency involved in ciliary motility
GO:0070509 calcium ion import
GO:0086010 membrane depolarization during action potential
Cellular Component
GO:0005886 plasma membrane
GO:0005929 cilium
GO:0016020 membrane
GO:0036128 CatSper complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Fertilization pathway
Sperm Motility And Taxes pathway
Reproduction pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q8NEC5
TrEMBL
UniProt Splice Variant
Entrez Gene 117144
UniGene Hs.189105
RefSeq NM_053054
HUGO HGNC:17116
OMIM 606389
CCDS CCDS8127
HPRD 09396
IMGT
EMBL AF407333 AP006287 BC032950 BC036522
GenPept AAH32950 AAH36522 AAL14105
ImmGen CATSPER1 (murine)
RNA Seq Atlas 117144