Homo sapiens Gene: CATSPER1

Summary
InnateDB Gene IDBG-58303.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol CATSPER1
Gene Name cation channel, sperm associated 1
Synonyms CATSPER; SPGF7
Species Homo sapiens
Ensembl Gene ENSG00000175294
Encoded Proteins
IDBP-58305 cation channel, sperm associated 1
Entrez Gene
Summary Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11: 65784223-65793988
Strand Reverse strand
Band q13.1
Transcripts
ENST00000312106  ENSP00000309052
ENST00000529244 
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein‑Protein  15
[view]
Protein‑DNA 1
[view]
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Predicted by orthology
Total [view]
Gene Ontology
Accession GO Term
Molecular Function
GO:0005216 ion channel activity
GO:0005245 voltage-gated calcium channel activity
GO:0005515 protein binding
Biological Process
GO:0001539 ciliary or flagellar motility
GO:0006811 ion transport
GO:0006816 calcium ion transport
GO:0007275 multicellular organismal development
GO:0007283 spermatogenesis
GO:0007342 fusion of sperm to egg plasma membrane
GO:0030154 cell differentiation
GO:0030317 sperm motility
GO:0051924 regulation of calcium ion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005929 cilium
GO:0016020 membrane
GO:0020017 flagellar membrane
GO:0036128 CatSper complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000038498 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000014720 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q8NEC5 
TrEMBL
UniProt Splice Variant
Entrez Gene 117144 
UniGene Hs.189105
RefSeq NM_053054 
HUGO 17116 
OMIM 606389
CCDS CCDS8127 
HPRD 09396
IMGT
EMBL AF407333 AP006287 BC032950 BC036522
GenPept AAH32950  AAH36522  AAL14105 
ImmGen CATSPER1 (murine) 
RNA Seq Atlas 117144