InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SCN3B

Summary

InnateDB Protein

IDBP-583164.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SCN3B

Protein Name

sodium channel, voltage-gated, type III, beta

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000432785

InnateDB Gene

IDBG-74903 (SCN3B)

Protein Structure

UniProt Annotation

Function

Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Brugada syndrome 7 (BRGDA7) [MIM:613120]: A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs, the individual will faint and may die in a few minutes if the heart is not reset. {ECO:0000269Ref.8}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005248	voltage-gated sodium channel activity
GO:0005515	protein binding
GO:0017080	sodium channel regulator activity
GO:0044325	ion channel binding
GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential

Biological Process

GO:0006814	sodium ion transport
GO:0007411	axon guidance
GO:0010460	positive regulation of heart rate
GO:0010765	positive regulation of sodium ion transport
GO:0035725	sodium ion transmembrane transport
GO:0051899	membrane depolarization
GO:0060048	cardiac muscle contraction
GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization
GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization
GO:0072659	protein localization to plasma membrane
GO:0086002	cardiac muscle cell action potential involved in contraction
GO:0086005	ventricular cardiac muscle cell action potential
GO:0086010	membrane depolarization during action potential
GO:0086012	membrane depolarization during cardiac muscle cell action potential
GO:0086014	atrial cardiac muscle cell action potential
GO:0086070	SA node cell to atrial cardiac muscle cell communication
GO:0086091	regulation of heart rate by cardiac conduction
GO:2000649	regulation of sodium ion transmembrane transporter activity