Version 5.4
Homo sapiens Gene: SCN3B
Summary
InnateDB Gene IDBG-74903.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SCN3B
Gene Name sodium channel, voltage-gated, type III, beta subunit
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000166257
Encoded Proteins
IDBP-74905
sodium channel, voltage-gated, type III, beta
IDBP-244986
sodium channel, voltage-gated, type III, beta
IDBP-583164
sodium channel, voltage-gated, type III, beta
IDBP-599889
sodium channel, voltage-gated, type III, beta
IDBP-586021
sodium channel, voltage-gated, type III, beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel beta subunit gene family, and influences the inactivation kinetics of the sodium channel. Two alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:123629187-123655244
Strand Reverse strand
Band q24.1
Transcripts
ENST00000299333 ENSP00000299333
ENST00000392770 ENSP00000376523
ENST00000527125
ENST00000530277 ENSP00000432785
ENST00000527836 ENSP00000435554
ENST00000528267 ENSP00000434363
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005248 voltage-gated sodium channel activity
GO:0005515 protein binding
GO:0017080 sodium channel regulator activity
GO:0044325 ion channel binding
GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential
Biological Process
GO:0006814 sodium ion transport
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0010460 positive regulation of heart rate
GO:0010765 positive regulation of sodium ion transport
GO:0019233 sensory perception of pain
GO:0035725 sodium ion transmembrane transport
GO:0051899 membrane depolarization
GO:0060048 cardiac muscle contraction
GO:0060371 regulation of atrial cardiac muscle cell membrane depolarization
GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization
GO:0061337 cardiac conduction
GO:0072659 protein localization to plasma membrane
GO:0086002 cardiac muscle cell action potential involved in contraction
GO:0086005 ventricular cardiac muscle cell action potential
GO:0086010 membrane depolarization during action potential
GO:0086012 membrane depolarization during cardiac muscle cell action potential
GO:0086014 atrial cardiac muscle cell action potential
GO:0086070 SA node cell to atrial cardiac muscle cell communication
GO:0086091 regulation of heart rate by cardiac conduction
GO:2000649 regulation of sodium ion transmembrane transporter activity
Cellular Component
GO:0001518 voltage-gated sodium channel complex
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030018 Z disc
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000049281
View Gene Order
ENSBTAG00000016768
Not yet available
Pathways
NETPATH
REACTOME
REACT_22266
Interaction between L1 and Ankyrins pathway
REACT_22205
L1CAM interactions pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
KEGG
INOH
PID NCI
p53downstreampathway
Direct p53 effectors
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.595649 Hs.743255
RefSeq NM_001040151 NM_018400
HUGO
OMIM
CCDS CCDS8442
HPRD 10497
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca