Version 5.4
Homo sapiens Protein: CACNA2D4
Summary
InnateDB Protein IDBP-583349.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CACNA2D4
Protein Name calcium channel, voltage-dependent, alpha 2/delta subunit 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000443038
InnateDB Gene IDBG-11938 (CACNA2D4)
Protein Structure
UniProt Annotation
Function The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. {ECO:0000269PubMed:12181424}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Disease Associations Retinal cone dystrophy 4 (RCD4) [MIM:610478]: Characterized by minimal symptoms except for slowly progressive reduction in visual acuity. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Predominantly expressed in certain types of endocrine cells. Present in the Paneth cells of the small intestine. Also present in the erythroblasts in the fetal liver, in the cells of the zona reticularis of the adrenal gland and in the basophils of the pituitary. Present at low level in some brain regions such as the cerebellum (at protein level). {ECO:0000269PubMed:12181424}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-Q7Z3S7
TrEMBL X6RLY7
UniProt Splice Variant
Entrez Gene 93589
UniGene Hs.13768
RefSeq
HUGO HGNC:20202
OMIM 608171
CCDS
HPRD 12182
IMGT
EMBL AC005342 AC005343
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca