InnateDB Protein
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IDBP-583363.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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IL15
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Protein Name
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interleukin 15
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Synonyms
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IL-15;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000436914
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InnateDB Gene
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IDBG-39028 (IL15)
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Protein Structure
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Function |
Cytokine that stimulates the proliferation of T- lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha.
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Subcellular Localization |
Isoform IL15-S48AA: Secreted.Isoform IL15-S21AA: Cytoplasm. Nucleus. Note=IL15-S21AA is not secreted, but rather is stored intracellularly, appearing in the nucleus and cytoplasmic components.
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Disease Associations |
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Tissue Specificity |
Most abundant in placenta and skeletal muscle. It is also detected in the heart, lung, liver and kidney. IL15- S21AA is preferentially expressed in tissues such as testis and thymus.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
13
[view]
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Protein-Protein |
10
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003443
Interleukin-15/Interleukin-21 family
IPR020439
Interleukin-15
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PFAM |
PF02372
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PRINTS |
PR01930
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P40933
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PhosphoSite |
PhosphoSite-P40933
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
3600
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UniGene |
Hs.735901
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RefSeq |
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HUGO |
HGNC:5977
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OMIM |
600554
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CCDS |
CCDS3756
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HPRD |
02776
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IMGT |
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EMBL |
AF031167
AK122993
AK290619
AY720442
BC018149
BC100961
BC100962
BC100963
CH471056
CR541980
CR542007
U14407
X91233
X94222
X94223
Y09908
Z38000
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GenPept |
AAA21551
AAB97518
AAH18149
AAI00962
AAI00963
AAI00964
AAU21241
BAF83308
BAG53839
CAA62616
CAA63913
CAA63914
CAA71044
CAA86100
CAG46777
CAG46804
EAX05083
EAX05084
EAX05085
EAX05086
EAX05087
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