InnateDB Protein
|
IDBP-583446.3
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
NOX4
|
Protein Name
|
NADPH oxidase 4
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000435474
|
InnateDB Gene
|
IDBG-67316 (NOX4)
|
Protein Structure
|
|
Function |
Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 5 and isoform 6 display reduced activity.Isoform 4: Involved in redox signaling in vascular cells. Constitutively and NADPH-dependently generates reactive oxygen species (ROS). Modulates the nuclear activation of ERK1/2 and the ELK1 transcription factor, and is capable of inducing nuclear DNA damage. Displays an increased activity relative to isoform 1.
|
Subcellular Localization |
Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell junction, focal adhesion {ECO:0000305}. Note=May localize to plasma membrane and focal adhesions. According to PubMed:15927447, may also localize to the nucleus.Isoform 4: Nucleus {ECO:0000269PubMed:23393389}. Nucleus, nucleolus {ECO:0000269PubMed:23393389}.
|
Disease Associations |
|
Tissue Specificity |
Expressed by distal tubular cells in kidney cortex and in endothelial cells (at protein level). Widely expressed. Strongly expressed in kidney and to a lower extent in heart, adipocytes, hepatoma, endothelial cells, skeletal muscle, brain, several brain tumor cell lines and airway epithelial cells. {ECO:0000269PubMed:11032835, ECO:0000269PubMed:11376945, ECO:0000269PubMed:15210697, ECO:0000269PubMed:16324151}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
5
[view]
|
Protein-Protein |
2
[view]
|
Protein-DNA |
3
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR005735
Zinc finger, LSD1-type
IPR013130
Ferric reductase transmembrane component-like domain
|
PFAM |
PF06943
PF01794
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9NPH5
|
PhosphoSite |
PhosphoSite-Q9NPH5
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
50507
|
UniGene |
Hs.591995
|
RefSeq |
|
HUGO |
HGNC:7891
|
OMIM |
605261
|
CCDS |
|
HPRD |
09243
|
IMGT |
|
EMBL |
AB041035
AF254621
AF261943
AJ704725
AJ704726
AJ704727
AJ704728
AJ704729
AK291830
AK298323
AP001815
AP002404
AP003400
AY288918
BC040105
BC051371
|
GenPept |
AAF68973
AAF87572
AAH40105
AAH51371
AAP41109
BAA95695
BAF84519
BAH12756
CAG28807
CAG28808
CAG28809
CAG28810
CAG28811
|
|
|