InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ST5

Summary

InnateDB Protein

IDBP-583528.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ST5

Protein Name

suppression of tumorigenicity 5

Synonyms

DENND2B; HTS1; p126;

Species

Homo sapiens

Ensembl Protein

ENSP00000436802

InnateDB Gene

IDBG-30831 (ST5)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. May be involved in cytoskeletal organization and tumorogenicity. Isoform 1 seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Isoform 3 may block ERK2 activation stimulated by ABL1. Isoform 3 may alter cell morphology and cell growth. {ECO:0000269PubMed:10229203, ECO:0000269PubMed:20937701, ECO:0000269PubMed:9632734}.

Subcellular Localization

Disease Associations

Tissue Specificity

Widely expressed with the exception of peripheral blood lymphocytes. Isoform 1 is expressed in several epithelial and fibroblast (including tumorigenic) but absent in lymphoid cell lines (at protein level). Isoform 3 is expressed in primary cell or weakly tumorigenic but not in tumorigenic cell lines (at protein level). {ECO:0000269PubMed:10229203}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.