Version 5.4
| Homo sapiens Gene: ST5 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-30831.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | ST5 | ||||||||||||||||||
| Gene Name | suppression of tumorigenicity 5 | ||||||||||||||||||
| Synonyms | DENND2B; HTS1; p126 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000166444 | ||||||||||||||||||
| Encoded Proteins |
suppression of tumorigenicity 5
suppression of tumorigenicity 5
suppression of tumorigenicity 5
suppression of tumorigenicity 5
suppression of tumorigenicity 5
suppression of tumorigenicity 5
suppression of tumorigenicity 5
suppression of tumorigenicity 5
suppression of tumorigenicity 5
suppression of tumorigenicity 5
suppression of tumorigenicity 5
suppression of tumorigenicity 5
suppression of tumorigenicity 5
suppression of tumorigenicity 5
suppression of tumorigenicity 5
suppression of tumorigenicity 5
suppression of tumorigenicity 5
suppression of tumorigenicity 5
suppression of tumorigenicity 5
suppression of tumorigenicity 5
suppression of tumorigenicity 5
suppression of tumorigenicity 5
suppression of tumorigenicity 5
suppression of tumorigenicity 5
suppression of tumorigenicity 5
suppression of tumorigenicity 5
suppression of tumorigenicity 5
suppression of tumorigenicity 5
suppression of tumorigenicity 5
suppression of tumorigenicity 5
suppression of tumorigenicity 5
suppression of tumorigenicity 5
suppression of tumorigenicity 5
suppression of tumorigenicity 5
suppression of tumorigenicity 5
suppression of tumorigenicity 5
suppression of tumorigenicity 5
suppression of tumorigenicity 5
suppression of tumorigenicity 5
suppression of tumorigenicity 5
suppression of tumorigenicity 5
suppression of tumorigenicity 5
suppression of tumorigenicity 5
suppression of tumorigenicity 5
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 11:8693351-8910951 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | p15.4 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| UniGene | Hs.117715 Hs.618531 Hs.732845 Hs.735137 Hs.736629 Hs.739074 | ||||||||||||||||||
| RefSeq | NM_005418 NM_139157 NM_213618 XM_005253077 XM_005253079 XM_005253080 XM_005253083 XM_005253084 XM_006718284 XM_006718285 | ||||||||||||||||||
| HUGO | |||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS7791 CCDS7792 | ||||||||||||||||||
| HPRD | 00780 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | |||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||