Homo sapiens Protein: FBXO27
Summary
InnateDB Protein IDBP-583537.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXO27
Protein Name F-box protein 27
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000437662
InnateDB Gene IDBG-49906 (FBXO27)
Protein Structure
UniProt Annotation
Function Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex- type oligosaccharides. {ECO:0000269PubMed:18203720}.
Subcellular Localization
Disease Associations
Tissue Specificity Predominantly expressed in brain, heart and kidney. Expressed at lower levels in liver and lung. {ECO:0000269PubMed:12383498}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0019005 SCF ubiquitin ligase complex
Protein Structure and Domains
PDB ID
InterPro IPR001810 F-box domain
IPR007397 F-box associated (FBA) domain
IPR008979 Galactose-binding domain-like
PFAM PF00646
PF12937
PF13013
PF04300
PRINTS
PIRSF
SMART SM00256
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NI29
PhosphoSite PhosphoSite-
TrEMBL M0R1C3
UniProt Splice Variant
Entrez Gene 126433
UniGene Hs.187461
RefSeq XP_006723080
HUGO HGNC:18753
OMIM 609099
CCDS CCDS12527
HPRD 16440
IMGT
EMBL AC010605 AC011455 AC093036 AF436061 BC014527 BC030060
GenPept AAH14527 AAH30060 AAM27918