InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTPRK

Summary

InnateDB Protein

IDBP-583624.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTPRK

Protein Name

protein tyrosine phosphatase, receptor type, K

Synonyms

R-PTP-kappa;

Species

Homo sapiens

Ensembl Protein

ENSP00000432973

InnateDB Gene

IDBG-96274 (PTPRK)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0016791	phosphatase activity
GO:0019901	protein kinase binding
GO:0045295	gamma-catenin binding

Biological Process

GO:0006470	protein dephosphorylation
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0008285	negative regulation of cell proliferation
GO:0010839	negative regulation of keratinocyte proliferation
GO:0016311	dephosphorylation
GO:0016477	cell migration
GO:0030336	negative regulation of cell migration
GO:0034394	protein localization to cell surface
GO:0034614	cellular response to reactive oxygen species
GO:0034644	cellular response to UV
GO:0045786	negative regulation of cell cycle
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048041	focal adhesion assembly

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0005911	cell-cell junction
GO:0005912	adherens junction
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031256	leading edge membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR000998 MAM domain
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR013098 Immunoglobulin I-set
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF00629
PF00041
PF01108
PF07679

PRINTS

PR00700
PR00020

PIRSF

SMART

SM00194
SM00137
SM00404
SM00409
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt