Version 5.4
Homo sapiens Gene: PTPRK
Summary
InnateDB Gene IDBG-96274.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPRK
Gene Name protein tyrosine phosphatase, receptor type, K
Synonyms R-PTP-kappa
Species Homo sapiens
Ensembl Gene ENSG00000152894
Encoded Proteins
IDBP-96278
protein tyrosine phosphatase, receptor type, K
IDBP-96280
protein tyrosine phosphatase, receptor type, K
IDBP-96284
protein tyrosine phosphatase, receptor type, K
IDBP-96286
protein tyrosine phosphatase, receptor type, K
IDBP-96288
protein tyrosine phosphatase, receptor type, K
IDBP-245623
protein tyrosine phosphatase, receptor type, K
IDBP-386879
protein tyrosine phosphatase, receptor type, K
IDBP-386880
protein tyrosine phosphatase, receptor type, K
IDBP-601341
protein tyrosine phosphatase, receptor type, K
IDBP-583624
protein tyrosine phosphatase, receptor type, K
IDBP-595272
protein tyrosine phosphatase, receptor type, K
IDBP-601364
protein tyrosine phosphatase, receptor type, K
IDBP-590376
protein tyrosine phosphatase, receptor type, K
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:127968779-128520674
Strand Reverse strand
Band q22.33
Transcripts
ENST00000368226 ENSP00000357209
ENST00000368215 ENSP00000357198
ENST00000368213 ENSP00000357196
ENST00000368210 ENSP00000357193
ENST00000368207 ENSP00000357190
ENST00000368205
ENST00000368202
ENST00000392449 ENSP00000376243
ENST00000415055 ENSP00000408180
ENST00000415046 ENSP00000406825
ENST00000434424
ENST00000429595
ENST00000490332 ENSP00000434058
ENST00000498284
ENST00000495748
ENST00000532331 ENSP00000432973
ENST00000531050 ENSP00000432960
ENST00000524481
ENST00000531466
ENST00000524534
ENST00000525459 ENSP00000434116
ENST00000532751 ENSP00000437299
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
Experimentally validated
Total 31 [view]
Protein-Protein 31 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0016791 phosphatase activity
GO:0019901 protein kinase binding
GO:0045295 gamma-catenin binding
Biological Process
GO:0006470 protein dephosphorylation
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0008285 negative regulation of cell proliferation
GO:0010839 negative regulation of keratinocyte proliferation
GO:0016311 dephosphorylation
GO:0016477 cell migration
GO:0030336 negative regulation of cell migration
GO:0034394 protein localization to cell surface
GO:0034614 cellular response to reactive oxygen species
GO:0034644 cellular response to UV
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0045786 negative regulation of cell cycle
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048041 focal adhesion assembly
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0005887 integral component of plasma membrane
GO:0005911 cell-cell junction
GO:0005912 adherens junction
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0031256 leading edge membrane
GO:0043025 neuronal cell body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019889
View Gene Order
ENSBTAG00000020829
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
nfat_tfpathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.155919
RefSeq NM_001135648 NM_001291983 NM_001291984 NM_002844 XM_005267085
HUGO
OMIM
CCDS CCDS47473 CCDS5137 CCDS75517
HPRD 03968
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca