Version 5.4
Homo sapiens Protein: SEMA7A
Summary
InnateDB Protein IDBP-583754.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEMA7A
Protein Name semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
Synonyms CD108; CDw108; H-SEMA-K1; H-Sema-L; JMH; SEMAK1; SEMAL;
Species Homo sapiens
Ensembl Protein ENSP00000438966
InnateDB Gene IDBG-22070 (SEMA7A)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0001649 osteoblast differentiation
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007229 integrin-mediated signaling pathway
GO:0007275 multicellular organismal development
GO:0007411 axon guidance
GO:0045773 positive regulation of axon extension
GO:0050727 regulation of inflammatory response
GO:0060907 positive regulation of macrophage cytokine production
GO:0070374 positive regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0031225 anchored component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001627 Sema domain
IPR002165 Plexin
IPR007110 Immunoglobulin-like domain
IPR016201 Plexin-like fold
PFAM PF01403
PF01437
PRINTS
PIRSF
SMART SM00630
SM00423
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75326
PhosphoSite PhosphoSite-O75326
TrEMBL H3BMF9
UniProt Splice Variant
Entrez Gene 8482
UniGene Hs.735823
RefSeq NP_001139501
HUGO HGNC:10741
OMIM 607961
CCDS CCDS53959
HPRD 07081
IMGT
EMBL AC012435 AC090826 AF030697 AF030698 AF069493 AF071542 AK001895 AK293280 AM180445 AM180446 AM180447 AM180448 AM180449 AM180450 AM180451 AY885237 BC101643 BC101647
GenPept AAC34261 AAC34741 AAC80456 AAC82642 AAI01644 AAI01648 AAW62253 BAG50988 BAG56808 CAJ55398 CAJ55399 CAJ55400 CAJ55401 CAJ55402 CAJ55403 CAJ55404

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca