Version 5.4
Homo sapiens Protein: POLE
Summary
InnateDB Protein IDBP-583803.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POLE
Protein Name polymerase (DNA directed), epsilon
Synonyms CRCS12; FILS; POLE1;
Species Homo sapiens
Ensembl Protein ENSP00000442578
InnateDB Gene IDBG-65706 (POLE)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006261 DNA-dependent DNA replication
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR006133 DNA-directed DNA polymerase, family B, exonuclease domain
IPR012337 Ribonuclease H-like domain
PFAM PF03104
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q9UNE8
UniProt Splice Variant
Entrez Gene 5426
UniGene Hs.616423
RefSeq
HUGO HGNC:9177
OMIM 174762
CCDS
HPRD 07177
IMGT
EMBL AC131212 AC135586 AF128542
GenPept AAD45663

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca