InnateDB Protein
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IDBP-58389.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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REG3G
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Protein Name
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regenerating islet-derived 3 gamma
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000272324
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InnateDB Gene
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IDBG-58387 (REG3G)
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Protein Structure
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Function |
Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. The uncleaved form has bacteriostatic activity, whereas the cleaved form has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. Regulates keratinocyte proliferation and differentiation after skin injury. {ECO:0000269PubMed:19095652}.
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Subcellular Localization |
Secreted. Cytoplasm {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Predominantly expressed in pancreas, where it may be restricted to exocrine pancreas. Moderate expression levels in testis and weak in heart, kidney and placenta. {ECO:0000269PubMed:15556304, ECO:0000269PubMed:15777617}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
GO:0002755
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MyD88-dependent toll-like receptor signaling pathway
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GO:0006953
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acute-phase response
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GO:0010838
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positive regulation of keratinocyte proliferation
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GO:0045617
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negative regulation of keratinocyte differentiation
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GO:0050830
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defense response to Gram-positive bacterium
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GO:0090303
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positive regulation of wound healing
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Cellular Component |
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PDB ID |
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InterPro |
IPR001304
C-type lectin
IPR016187
C-type lectin fold
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PFAM |
PF00059
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PRINTS |
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PIRSF |
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SMART |
SM00034
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TIGRFAMs |
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Modification |
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SwissProt |
Q6UW15
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
130120
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UniGene |
Hs.742463
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RefSeq |
NP_001008388
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HUGO |
HGNC:29595
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OMIM |
609933
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CCDS |
CCDS1962
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HPRD |
10137
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IMGT |
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EMBL |
AB161037
AB161038
AB161039
AC017004
AK292595
AY359047
AY428734
BC103852
BC103853
BC103854
CH471053
CR541938
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GenPept |
AAI03853
AAI03854
AAI03855
AAQ89406
AAR88147
AAX88840
BAD51394
BAD51395
BAD51396
BAF85284
CAG46736
EAW99580
EAW99581
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