InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAOB

Summary

InnateDB Protein

IDBP-58403.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAOB

Protein Name

monoamine oxidase B

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000367309

InnateDB Gene

IDBG-58401 (MAOB)

Protein Structure

UniProt Annotation

Function

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.

Subcellular Localization

Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008131	primary amine oxidase activity
GO:0009055	electron carrier activity
GO:0016491	oxidoreductase activity
GO:0042803	protein homodimerization activity
GO:0050660	flavin adenine dinucleotide binding

Biological Process

GO:0006805	xenobiotic metabolic process
GO:0009636	response to toxic substance
GO:0010044	response to aluminum ion
GO:0010269	response to selenium ion
GO:0014063	negative regulation of serotonin secretion
GO:0021762	substantia nigra development
GO:0032496	response to lipopolysaccharide
GO:0042493	response to drug
GO:0044281	small molecule metabolic process
GO:0045471	response to ethanol
GO:0045964	positive regulation of dopamine metabolic process
GO:0048545	response to steroid hormone
GO:0051412	response to corticosterone
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005740	mitochondrial envelope
GO:0005741	mitochondrial outer membrane
GO:0005743	mitochondrial inner membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001327 Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain
IPR001613 Flavin amine oxidase
IPR002937 Amine oxidase
IPR002938 Monooxygenase, FAD-binding
IPR003953 FAD binding domain
IPR006076 FAD dependent oxidoreductase

PFAM

PF00070
PF01593
PF01494
PF00890
PF01266

PRINTS

PR00757

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P27338