InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MAOB

Summary

InnateDB Gene

IDBG-58401.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAOB

Gene Name

monoamine oxidase B

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000069535

Encoded Proteins

IDBP-58403

monoamine oxidase B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:43766611-43882447

Strand

Reverse strand

Band

p11.3

Transcripts

ENST00000378069	ENSP00000367309
ENST00000487544
ENST00000468431

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008131	primary amine oxidase activity
GO:0009055	electron carrier activity
GO:0016491	oxidoreductase activity
GO:0042803	protein homodimerization activity
GO:0050660	flavin adenine dinucleotide binding

Biological Process

GO:0006805	xenobiotic metabolic process
GO:0009636	response to toxic substance
GO:0010044	response to aluminum ion
GO:0010269	response to selenium ion
GO:0014063	negative regulation of serotonin secretion
GO:0021762	substantia nigra development
GO:0032496	response to lipopolysaccharide
GO:0042493	response to drug
GO:0044281	small molecule metabolic process
GO:0045471	response to ethanol
GO:0045964	positive regulation of dopamine metabolic process
GO:0048545	response to steroid hormone
GO:0051412	response to corticosterone
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005740	mitochondrial envelope
GO:0005741	mitochondrial outer membrane
GO:0005743	mitochondrial inner membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome