InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DTX1

Summary

InnateDB Protein

IDBP-58412.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DTX1

Protein Name

deltex homolog 1 (Drosophila)

Synonyms

hDx-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000257600

InnateDB Gene

IDBG-58410 (DTX1)

Protein Structure

UniProt Annotation

Function

Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T- cell development, suggesting that it can antagonize NOTCH1. {ECO:0000250, ECO:0000269PubMed:11564735, ECO:0000269PubMed:11869684, ECO:0000269PubMed:9590294}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Associates with endocytic vesicles. Partially nuclear.

Disease Associations

Tissue Specificity

Widely expressed. Strongly expressed in blood vessel. Also expressed in embryonic nervous system, pancreas, lung, adrenal gland, digestive tube and muscles. Expressed in MZB cells and developing B- and T-cells. {ECO:0000269PubMed:12753744, ECO:0000269PubMed:9590294}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.

Experimentally validated
Total	30 [view]
Protein-Protein	30 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0005112	Notch binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0017124	SH3 domain binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007166	cell surface receptor signaling pathway
GO:0007219	Notch signaling pathway
GO:0008593	regulation of Notch signaling pathway
GO:0010001	glial cell differentiation
GO:0016567	protein ubiquitination
GO:0045581	negative regulation of T cell differentiation
GO:0045665	negative regulation of neuron differentiation
GO:2001141	regulation of RNA biosynthetic process