Version 5.4
Homo sapiens Protein: SLC8A3
Summary
InnateDB Protein IDBP-584194.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC8A3
Protein Name solute carrier family 8 (sodium/calcium exchanger), member 3
Synonyms NCX3;
Species Homo sapiens
Ensembl Protein ENSP00000436688
InnateDB Gene IDBG-10629 (SLC8A3)
Protein Structure
UniProt Annotation
Function Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores (By similarity). {ECO:0000250}.
Subcellular Localization Membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Isoform 2 is expressed in brain and skeletal muscle. Isoform 3 is expressed in excitable cells of brain, retina and skeletal muscle. Isoform 4 is expressed in skeletal muscle. {ECO:0000269PubMed:15777725}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005432 calcium:sodium antiporter activity
GO:0005516 calmodulin binding
Biological Process
GO:0006811 ion transport
GO:0006816 calcium ion transport
GO:0007154 cell communication
GO:0007596 blood coagulation
GO:0035725 sodium ion transmembrane transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR003644 Na-Ca exchanger/integrin-beta4
IPR004836 Sodium/calcium exchanger protein
IPR004837 Sodium/calcium exchanger membrane region
PFAM PF03160
PF01699
PRINTS PR01259
PIRSF
SMART SM00237
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P57103
PhosphoSite PhosphoSite-P57103
TrEMBL Q86TQ9
UniProt Splice Variant
Entrez Gene 6547
UniGene Hs.715967
RefSeq NP_489479
HUGO HGNC:11070
OMIM 607991
CCDS CCDS53904
HPRD 09723
IMGT
EMBL AF508982 AF510501 AF510502 AF510503 AJ304852 AJ304853 AJ745101 AJ745102 AL135747 AL160191 BC142969 BX248763 CH471061 X93017
GenPept AAI42970 AAM90955 AAN60790 AAN60791 AAN60792 CAC40984 CAC40985 CAD66570 CAG33739 CAG33740 EAW81019 EAW81021 EAW81026

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca