InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LPAR2

Summary

InnateDB Protein

IDBP-584201.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LPAR2

Protein Name

lysophosphatidic acid receptor 2

Synonyms

EDG-4; EDG4; LPA-2; LPA2;

Species

Homo sapiens

Ensembl Protein

ENSP00000443256

InnateDB Gene

IDBG-40085 (LPAR2)

Protein Structure

UniProt Annotation

Function

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation. {ECO:0000269PubMed:15143197, ECO:0000269PubMed:19306925}.

Subcellular Localization

Cell surface {ECO:0000269PubMed:19306925}. Cell membrane {ECO:0000269PubMed:19306925}; Multi-pass membrane protein {ECO:0000269PubMed:19306925}. Note=Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA colocalizes with RALA in the endocytic vesicles.

Disease Associations

Tissue Specificity

Expressed most abundantly in testes and peripheral blood leukocytes with less expression in pancreas, spleen, thymus and prostate. Little or no expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney, ovary, small intestine, or colon.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0008289	lipid binding
GO:0030165	PDZ domain binding
GO:0070915	lysophosphatidic acid receptor activity

Biological Process

GO:0000187	activation of MAPK activity
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0035025	positive regulation of Rho protein signal transduction
GO:0043410	positive regulation of MAPK cascade

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0030139	endocytic vesicle

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001671 Melanocortin/ACTH receptor
IPR002277 Lysophosphatidic acid receptor EDG-2
IPR004061 Sphingosine 1-phosphate receptor
IPR004065 Lysophosphatidic acid receptor
IPR004066 Lysophosphatidic acid receptor EDG-4
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00534
PR01148
PR01523
PR01527
PR01528

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9HBW0