InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ITGB3

Summary

InnateDB Protein

IDBP-584429.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGB3

Protein Name

integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)

Synonyms

BDPLT16; BDPLT2; CD61; GP3A; GPIIIa; GT;

Species

Homo sapiens

Ensembl Protein

ENSP00000452786

InnateDB Gene

IDBG-547297 (ITGB3)

Protein Structure

UniProt Annotation

Function

Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:20702409}; Single-pass type I membrane protein {ECO:0000269PubMed:20702409}. Cell projection, lamellipodium membrane {ECO:0000269PubMed:20702409}. Cell junction, focal adhesion {ECO:0000269PubMed:20702409}.

Disease Associations

Glanzmann thrombasthenia (GT) [MIM:273800]: A common inherited disease of platelet aggregation. It is characterized by mucocutaneous bleeding of mild-to-moderate severity. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb-IIIa complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the GPIIb-IIIa complex at reduced levels, have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. {ECO:0000269PubMed:10233432, ECO:0000269PubMed:11588040, ECO:0000269PubMed:11897046, ECO:0000269PubMed:12083483, ECO:0000269PubMed:12353082, ECO:0000269PubMed:1371279, ECO:0000269PubMed:1438206, ECO:0000269PubMed:15583747, ECO:0000269PubMed:15634267, ECO:0000269PubMed:15748237, ECO:0000269PubMed:1602006, ECO:0000269PubMed:20020534, ECO:0000269PubMed:2392682, ECO:0000269PubMed:8781422, ECO:0000269PubMed:9215749, ECO:0000269PubMed:9376589, ECO:0000269PubMed:9684783, ECO:0000269PubMed:9790984}. Note=The disease is caused by mutations affecting the gene represented in this entry.Bleeding disorder, platelet-type 16 (BDPLT16) [MIM:187800]: An autosomal dominant form of congenital macrothrombocytopenia associated with platelet anisocytosis. It is a disorder of platelet production. Affected individuals may have no or only mildly increased bleeding tendency. In vitro studies show mild platelet functional abnormalities. {ECO:0000269PubMed:18065693}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	62 [view]
Protein-Protein	62 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003756	protein disulfide isomerase activity
GO:0004872	receptor activity
GO:0005161	platelet-derived growth factor receptor binding
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0043184	vascular endothelial growth factor receptor 2 binding
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0001938	positive regulation of endothelial cell proliferation
GO:0002576	platelet degranulation
GO:0006457	protein folding
GO:0007044	cell-substrate junction assembly
GO:0007155	cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007275	multicellular organismal development
GO:0007411	axon guidance
GO:0007596	blood coagulation
GO:0010595	positive regulation of endothelial cell migration
GO:0010745	negative regulation of macrophage derived foam cell differentiation
GO:0010888	negative regulation of lipid storage
GO:0014909	smooth muscle cell migration
GO:0016032	viral process
GO:0030168	platelet activation
GO:0030198	extracellular matrix organization
GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031589	cell-substrate adhesion
GO:0032147	activation of protein kinase activity
GO:0032369	negative regulation of lipid transport
GO:0035295	tube development
GO:0042060	wound healing
GO:0045087	innate immune response (InnateDB)
GO:0045124	regulation of bone resorption
GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050748	negative regulation of lipoprotein metabolic process
GO:0050900	leukocyte migration
GO:0060055	angiogenesis involved in wound healing
GO:0070527	platelet aggregation

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005925	focal adhesion
GO:0008305	integrin complex
GO:0009986	cell surface
GO:0016020	membrane
GO:0031092	platelet alpha granule membrane
GO:0031258	lamellipodium membrane
GO:0042470	melanosome
GO:0043235	receptor complex
GO:0070062	extracellular vesicular exosome
GO:0071062	alphav-beta3 integrin-vitronectin complex

Protein Structure and Domains

PDB ID

InterPro

IPR002035 von Willebrand factor, type A
IPR002369 Integrin beta subunit, N-terminal
IPR012896 Integrin beta subunit, tail
IPR013111 EGF-like domain, extracellular
IPR014836 Integrin beta subunit, cytoplasmic domain
IPR015812 Integrin beta subunit
IPR016201 Plexin-like fold

PFAM

PF00092
PF00362
PF07965
PF07974
PF08725

PRINTS

PR01186

PIRSF

PIRSF002512

SMART

SM00327
SM00187
SM00423

TIGRFAMs

Post-translational Modifications

Modification

Cross-References