InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ITGB3

Summary

InnateDB Gene

IDBG-547297.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGB3

Gene Name

integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)

Synonyms

BDPLT16; BDPLT2; CD61; GP3A; GPIIIa; GT

Species

Homo sapiens

Ensembl Gene

ENSG00000259207

Encoded Proteins

IDBP-584429

integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)

IDBP-757874

IDBP-761069

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 23150579

ITGAV::ITGB3 is a sensor and activator of innate immunity to herpes simplex virus-1.

Entrez Gene

Summary

The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:47253846-47311816

Strand

Forward strand

Band

q21.32

Transcripts

ENST00000559488	ENSP00000452786
ENST00000571680	ENSP00000461626
ENST00000573377	ENSP00000465586

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	62 [view]
Protein-Protein	62 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003756	protein disulfide isomerase activity
GO:0004872	receptor activity
GO:0005161	platelet-derived growth factor receptor binding
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0043184	vascular endothelial growth factor receptor 2 binding
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0001938	positive regulation of endothelial cell proliferation
GO:0002576	platelet degranulation
GO:0006457	protein folding
GO:0007044	cell-substrate junction assembly
GO:0007155	cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007275	multicellular organismal development
GO:0007411	axon guidance
GO:0007596	blood coagulation
GO:0010595	positive regulation of endothelial cell migration
GO:0010745	negative regulation of macrophage derived foam cell differentiation
GO:0010888	negative regulation of lipid storage
GO:0014909	smooth muscle cell migration
GO:0016032	viral process
GO:0030168	platelet activation
GO:0030198	extracellular matrix organization
GO:0030334	regulation of cell migration
GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031589	cell-substrate adhesion
GO:0032147	activation of protein kinase activity
GO:0032369	negative regulation of lipid transport
GO:0035295	tube development
GO:0042060	wound healing
GO:0045087	innate immune response (InnateDB)
GO:0045124	regulation of bone resorption
GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050748	negative regulation of lipoprotein metabolic process
GO:0050900	leukocyte migration
GO:0060055	angiogenesis involved in wound healing
GO:0070527	platelet aggregation

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005925	focal adhesion
GO:0008305	integrin complex
GO:0009986	cell surface
GO:0016020	membrane
GO:0031092	platelet alpha granule membrane
GO:0031258	lamellipodium membrane
GO:0042470	melanosome
GO:0043235	receptor complex
GO:0070062	extracellular vesicular exosome
GO:0071062	alphav-beta3 integrin-vitronectin complex