InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: USP22

Summary

InnateDB Protein

IDBP-584538.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

USP22

Protein Name

ubiquitin specific peptidase 22

Synonyms

USP3L;

Species

Homo sapiens

Ensembl Protein

ENSP00000440950

InnateDB Gene

IDBG-35418 (USP22)

Protein Structure

UniProt Annotation

Function

Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression. {ECO:0000269PubMed:18206972, ECO:0000269PubMed:18206973, ECO:0000269PubMed:18469533}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Moderately expressed in various tissues including heart and skeletal muscle, and weakly expressed in lung and liver. {ECO:0000269PubMed:16378762}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.

Experimentally validated
Total	51 [view]
Protein-Protein	51 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0010485	H4 histone acetyltransferase activity
GO:0019899	enzyme binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0036459	ubiquitinyl hydrolase activity

Biological Process

GO:0006325	chromatin organization
GO:0006351	transcription, DNA-templated
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007049	cell cycle
GO:0009790	embryo development
GO:0016574	histone ubiquitination
GO:0016578	histone deubiquitination
GO:0016579	protein deubiquitination
GO:0043967	histone H4 acetylation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045931	positive regulation of mitotic cell cycle

Cellular Component

GO:0000124	SAGA complex
GO:0070461	SAGA-type complex

Protein Structure and Domains

PDB ID

InterPro

IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR001607 Zinc finger, UBP-type
IPR028889 Ubiquitin carboxyl-terminal hydrolase-like domain

PFAM

PF00443
PF02148

PRINTS

PIRSF

SMART

SM00290

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9UPT9