InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PGF

Summary

InnateDB Protein

IDBP-584581.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PGF

Protein Name

placental growth factor

Synonyms

D12S1900; PGFL; PLGF; PlGF-2; SHGC-10760;

Species

Homo sapiens

Ensembl Protein

ENSP00000451040

InnateDB Gene

IDBG-12625 (PGF)

Protein Structure

UniProt Annotation

Function

Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth. {ECO:0000269PubMed:21215706}.

Subcellular Localization

Secreted. Note=The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin.

Disease Associations

Tissue Specificity

While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0008201	heparin binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001666	response to hypoxia
GO:0001938	positive regulation of endothelial cell proliferation
GO:0002040	sprouting angiogenesis
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0007565	female pregnancy
GO:0008284	positive regulation of cell proliferation
GO:0030154	cell differentiation
GO:0031100	organ regeneration
GO:0032870	cellular response to hormone stimulus
GO:0042493	response to drug
GO:0045766	positive regulation of angiogenesis
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0051781	positive regulation of cell division
GO:0060688	regulation of morphogenesis of a branching structure