Version 5.4
Homo sapiens Protein: IAPP
Summary
InnateDB Protein IDBP-584584.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IAPP
Protein Name islet amyloid polypeptide
Synonyms DAP; IAP;
Species Homo sapiens
Ensembl Protein ENSP00000437357
InnateDB Gene IDBG-22720 (IAPP)
Protein Structure
UniProt Annotation
Function Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
Subcellular Localization Secreted {ECO:0000269PubMed:17374526}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005179 hormone activity
GO:0042802 identical protein binding
Biological Process
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0031018 endocrine pancreas development
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR000443 Pro-islet amyloid polypeptide
IPR001693 Calcitonin peptide-like
IPR021116 Procalcitonin/adrenomedullin
PFAM PF00214
PRINTS PR00818
PIRSF
SMART SM00113
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P10997
PhosphoSite PhosphoSite-P10997
TrEMBL F5H0S1
UniProt Splice Variant
Entrez Gene 3375
UniGene Hs.707796
RefSeq
HUGO HGNC:5329
OMIM 147940
CCDS CCDS8688
HPRD 01005
IMGT
EMBL AC006559 AC022224 CH471094 DQ516082 J04422 M21785 M26650 M27503 X13859 X14902 X14903 X14904 X14905 X52818 X52819 X55634 X56030 X68830
GenPept AAA35524 AAA35983 AAA51728 AAA52281 ABG27010 CAA33031 CAA33032 CAA33033 CAA37002 CAA39504 CAA48724 CAB57803 CAB57804 EAW96426 EAW96427

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca