InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DCTN2

Summary

InnateDB Protein

IDBP-584617.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DCTN2

Protein Name

dynactin 2 (p50)

Synonyms

DCTN50; DYNAMITIN; HEL-S-77; RBP50;

Species

Homo sapiens

Ensembl Protein

ENSP00000447824

InnateDB Gene

IDBG-42885 (DCTN2)

Protein Structure

UniProt Annotation

Function

Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.

Subcellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:8647893}. Membrane {ECO:0000269PubMed:8647893}; Peripheral membrane protein {ECO:0000269PubMed:8647893}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	67 [view]
Protein-Protein	67 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003774	motor activity
GO:0005515	protein binding
GO:0030507	spectrin binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0007052	mitotic spindle organization
GO:0007067	mitotic nuclear division
GO:0008152	metabolic process
GO:0008283	cell proliferation
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II

Cellular Component

GO:0000776	kinetochore
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005869	dynactin complex
GO:0005874	microtubule
GO:0016020	membrane
GO:0030286	dynein complex
GO:0031982	vesicle
GO:0070062	extracellular vesicular exosome