Version 5.4
Homo sapiens Protein: APAF1
Summary
InnateDB Protein IDBP-585006.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APAF1
Protein Name apoptotic peptidase activating factor 1
Synonyms APAF-1; CED4;
Species Homo sapiens
Ensembl Protein ENSP00000450175
InnateDB Gene IDBG-52364 (APAF1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 37 [view]
Protein-Protein 37 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0042981 regulation of apoptotic process
Cellular Component
GO:0005622 intracellular
Protein Structure and Domains
PDB ID
InterPro IPR001315 CARD domain
IPR011029 Death-like domain
PFAM PF00619
PRINTS
PIRSF
SMART SM00114
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F8VNZ0
UniProt Splice Variant
Entrez Gene 317
UniGene Hs.713249
RefSeq
HUGO HGNC:576
OMIM 602233
CCDS
HPRD 03755
IMGT
EMBL AC011248 AC013283
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca