InnateDB Protein
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IDBP-58513.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CPLX2
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Protein Name
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complexin 2
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Synonyms
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921-L; CPX-2; CPX2; Hfb1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000352544
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InnateDB Gene
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IDBG-58509 (CPLX2)
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Protein Structure
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Function |
Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in synaptic vesicle exocytosis. Also involved in mast cell exocytosis (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm, cytosol. Note=Enriched at synaptic-releasing sites in mature neurons. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Nervous system. In hippocampus and cerebellum, expressed mainly by excitatory neurons. Down-regulated in brain cortex from patients suffering from Huntington disease, bipolar disorder or major depression. Down-regulated in cerebellum from patients with schizophrenia. {ECO:0000269PubMed:11483314, ECO:0000269PubMed:11576753, ECO:0000269PubMed:15906159, ECO:0000269PubMed:16162394, ECO:0000269PubMed:9853440}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR008849
Synaphin
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PFAM |
PF05835
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6PUV4
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PhosphoSite |
PhosphoSite-Q6PUV4
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TrEMBL |
D6RGY3
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UniProt Splice Variant |
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Entrez Gene |
10814
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UniGene |
Hs.193235
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RefSeq |
NP_006641
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HUGO |
HGNC:2310
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OMIM |
605033
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CCDS |
CCDS4396
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HPRD |
09234
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IMGT |
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EMBL |
AC010241
AC018760
AC138965
AK314177
AY576870
BC093706
BC112287
BN000499
BN000500
U35100
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GenPept |
AAC50229
AAH93706
AAI12288
AAS93622
BAG36859
CAG26663
CAG26664
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