InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DDX54

Summary

InnateDB Protein

IDBP-58516.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DDX54

Protein Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 54

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000323858

InnateDB Gene

IDBG-58514 (DDX54)

Protein Structure

UniProt Annotation

Function

Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors. {ECO:0000269PubMed:12466272}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000269PubMed:12429849}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.

Experimentally validated
Total	19 [view]
Protein-Protein	18 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0003723	RNA binding
GO:0004004	ATP-dependent RNA helicase activity
GO:0005102	receptor binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0016787	hydrolase activity
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0030331	estrogen receptor binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006396	RNA processing
GO:0016070	RNA metabolic process
GO:0030520	intracellular estrogen receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001650 Helicase, C-terminal
IPR006935 Helicase/UvrB domain
IPR011545 DEAD/DEAH box helicase domain
IPR012541 DBP10CT
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR014014 RNA helicase, DEAD-box type, Q motif
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF04851
PF00270
PF08147

PRINTS

PIRSF

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8TDD1