InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DDX54

Summary

InnateDB Gene

IDBG-58514.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DDX54

Gene Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 54

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000123064

Encoded Proteins

IDBP-58516

DEAD (Asp-Glu-Ala-Asp) box polypeptide 54

IDBP-58518

DEAD (Asp-Glu-Ala-Asp) box polypeptide 54

IDBP-604092

DEAD (Asp-Glu-Ala-Asp) box polypeptide 54

IDBP-604095

DEAD (Asp-Glu-Ala-Asp) box polypeptide 54

IDBP-604096

DEAD (Asp-Glu-Ala-Asp) box polypeptide 54

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The nucleolar protein encoded by this gene interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. Alternative splice variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:113157174-113185479

Strand

Reverse strand

Band

q24.13

Transcripts

ENST00000314045	ENSP00000323858
ENST00000306014	ENSP00000304072
ENST00000549271
ENST00000551912
ENST00000546898	ENSP00000447098
ENST00000550016
ENST00000548786
ENST00000551344	ENSP00000448189
ENST00000552375	ENSP00000448477
ENST00000546869

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.

Experimentally validated
Total	19 [view]
Protein-Protein	18 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0003723	RNA binding
GO:0004004	ATP-dependent RNA helicase activity
GO:0005102	receptor binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0016787	hydrolase activity
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0030331	estrogen receptor binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006396	RNA processing
GO:0016070	RNA metabolic process
GO:0030520	intracellular estrogen receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0016020	membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000029599

View Gene Order

ENSBTAG00000011930

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

erb_genomic_pathway

Validated nuclear estrogen receptor beta network

era_genomic_pathway

Validated nuclear estrogen receptor alpha network

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.506861

RefSeq

NM_001111322 NM_024072

HUGO

OMIM

CCDS

CCDS31907 CCDS44984

HPRD

13129

IMGT

EMBL

GenPept

RNA Seq Atlas