InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: THOC3

Summary

InnateDB Protein

IDBP-58547.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

THOC3

Protein Name

THO complex 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000265097

InnateDB Gene

IDBG-58545 (THOC3)

Protein Structure

UniProt Annotation

Function

Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269PubMed:11979277, ECO:0000269PubMed:15833825, ECO:0000269PubMed:15998806, ECO:0000269PubMed:17190602, ECO:0000269PubMed:18974867}.

Subcellular Localization

Nucleus {ECO:0000305}. Nucleus speckle {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	30 [view]
Protein-Protein	28 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding

Biological Process

GO:0006397	mRNA processing
GO:0006406	mRNA export from nucleus
GO:0008380	RNA splicing
GO:0046784	intronless viral mRNA export from host nucleus

Cellular Component

GO:0000346	transcription export complex
GO:0000445	THO complex part of transcription export complex
GO:0016607	nuclear speck

Protein Structure and Domains

PDB ID

InterPro

IPR001680 WD40 repeat
IPR011659 WD40-like Beta Propeller
IPR013979 Translation initiation factor, beta propellor-like domain
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat

PFAM

PF00400
PF07676
PF08662

PRINTS

PR00320

PIRSF

SMART

SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt