Homo sapiens Protein: RERG | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Protein | IDBP-585554.3 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | RERG | ||||||||||||||
Protein Name | RAS-like, estrogen-regulated, growth inhibitor | ||||||||||||||
Synonyms | |||||||||||||||
Species | Homo sapiens | ||||||||||||||
Ensembl Protein | ENSP00000438280 | ||||||||||||||
InnateDB Gene | IDBG-21429 (RERG) | ||||||||||||||
Protein Structure | |||||||||||||||
UniProt Annotation | |||||||||||||||
Function | Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential. {ECO:0000269PubMed:11533059}. | ||||||||||||||
Subcellular Localization | Cytoplasm {ECO:0000269PubMed:11533059}. | ||||||||||||||
Disease Associations | |||||||||||||||
Tissue Specificity | Detected in heart, brain, placenta, lung, liver, skin, kidney and pancreas. Detected in estrogen receptor- positive breast-derived cell lines, but not in estrogen receptor- negative cell lines. Expression is decreased or lost in a significant proportion of primary breast tumors with poor clinical prognosis. {ECO:0000269PubMed:11533059}. | ||||||||||||||
Comments | |||||||||||||||
Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||
PDB ID | |||||||||||||||
InterPro |
IPR001806
Small GTPase superfamily IPR003578 Small GTPase superfamily, Rho type IPR003579 Small GTPase superfamily, Rab type IPR005225 Small GTP-binding protein domain IPR006689 Small GTPase superfamily, ARF/SAR type IPR013684 Mitochondrial Rho-like IPR020849 Small GTPase superfamily, Ras type IPR027417 P-loop containing nucleoside triphosphate hydrolase |
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PFAM |
PF00071
PF00025 PF08477 |
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PRINTS |
PR00449
PR00328 |
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PIRSF | |||||||||||||||
SMART |
SM00174
SM00175 SM00173 |
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TIGRFAMs | |||||||||||||||
Post-translational Modifications | |||||||||||||||
Modification | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | Q96A58 | ||||||||||||||
PhosphoSite | PhosphoSite-Q96A58 | ||||||||||||||
TrEMBL | F5GYR1 | ||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 85004 | ||||||||||||||
UniGene | Hs.199487 | ||||||||||||||
RefSeq | |||||||||||||||
HUGO | HGNC:15980 | ||||||||||||||
OMIM | 612664 | ||||||||||||||
CCDS | CCDS8673 | ||||||||||||||
HPRD | 15238 | ||||||||||||||
IMGT | |||||||||||||||
EMBL | AC007543 AC022334 AC092183 AF339750 AK295343 AK313881 BC007997 CH471094 | ||||||||||||||
GenPept | AAH07997 AAK98530 BAG36607 BAG58314 EAW96345 EAW96346 | ||||||||||||||