InnateDB Protein
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IDBP-585581.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ATP1A4
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Protein Name
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ATPase, Na+/K+ transporting, alpha 4 polypeptide
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Synonyms
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ATP1A1; ATP1AL2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000433094
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InnateDB Gene
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IDBG-103998 (ATP1A4)
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Protein Structure
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Function |
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility.
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:16175638}; Multi-pass membrane protein {ECO:0000269PubMed:16175638}. Note=In mature sperm, located in the principle piece of the sperm flagellum.
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Disease Associations |
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Tissue Specificity |
Specifically expressed in testis. Found in very low levels in skeletal muscle. Expressed in mature sperm (at protein level).
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR006068
Cation-transporting P-type ATPase, C-terminal
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PFAM |
PF00689
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q13733
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PhosphoSite |
PhosphoSite-Q13733
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
480
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UniGene |
Hs.662219
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RefSeq |
NP_001001734
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HUGO |
HGNC:14073
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OMIM |
607321
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CCDS |
CCDS44255
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HPRD |
09541
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IMGT |
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EMBL |
AF310646
AF352828
AF390027
AF421887
AF430843
AF459737
AF506797
AH002997
AK098076
AL121987
AY039031
BC028297
BC094801
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GenPept |
AAA60941
AAH28297
AAH94801
AAK72396
AAL35818
AAL66357
AAM20793
AAQ07964
BAC05228
CAI15274
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