InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BAI2

Summary

InnateDB Protein

IDBP-585614.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BAI2

Protein Name

brain-specific angiogenesis inhibitor 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000435397

InnateDB Gene

IDBG-95490 (BAI2)

Protein Structure

UniProt Annotation

Function

Might be involved in angiogenesis inhibition.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Strongly expressed in brain. Also detected in heart, thymus, skeletal muscle, and different cell lines.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0016525	negative regulation of angiogenesis

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000203 GPS motif
IPR000832 GPCR, family 2, secretin-like
IPR000884 Thrombospondin, type 1 repeat
IPR001879 GPCR, family 2, extracellular hormone receptor domain
IPR008077 GPCR, family 2, brain-specific angiogenesis inhibitor
IPR017981 GPCR, family 2-like
IPR022624 Domain of unknown function DUF3497

PFAM

PF01825
PF00002
PF00090
PF02793
PF12003

PRINTS

PR00249
PR01694

PIRSF

SMART

SM00303
SM00209
SM00008

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt