Version 5.4
Homo sapiens Gene: BAI2
Summary
InnateDB Gene IDBG-95490.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BAI2
Gene Name brain-specific angiogenesis inhibitor 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000121753
Encoded Proteins
IDBP-95492
brain-specific angiogenesis inhibitor 2
IDBP-95494
brain-specific angiogenesis inhibitor 2
IDBP-232760
brain-specific angiogenesis inhibitor 2
IDBP-232762
brain-specific angiogenesis inhibitor 2
IDBP-232764
brain-specific angiogenesis inhibitor 2
IDBP-232766
brain-specific angiogenesis inhibitor 2
IDBP-378479
brain-specific angiogenesis inhibitor 2
IDBP-378480
brain-specific angiogenesis inhibitor 2
IDBP-585614
brain-specific angiogenesis inhibitor 2
IDBP-600853
brain-specific angiogenesis inhibitor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis. [provided by RefSeq, Jul 2008]
This gene encodes a a seven-span transmembrane protein that is thought to be a member of the secretin receptor family. The encoded protein is a brain-specific inhibitor of angiogenesis. The mature peptide may be further cleaved into additional products (PMID:20367554). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:31727117-31764893
Strand Reverse strand
Band p35.2
Transcripts
ENST00000373658 ENSP00000362762
ENST00000373655 ENSP00000362759
ENST00000398556 ENSP00000381564
ENST00000398547 ENSP00000381555
ENST00000398542 ENSP00000381550
ENST00000398538 ENSP00000381548
ENST00000420125 ENSP00000410921
ENST00000436464 ENSP00000414758
ENST00000465256
ENST00000466109
ENST00000468430
ENST00000530999
ENST00000527361 ENSP00000435397
ENST00000530134
ENST00000533175 ENSP00000437219
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007422 peripheral nervous system development
GO:0016525 negative regulation of angiogenesis
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028782
View Gene Order
ENSBTAG00000010657
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.524138
RefSeq NM_001294335 NM_001294336 NM_001703 XM_005271067 XM_006710783 XM_006710784 XM_006710785 XM_006710788 XM_006710789
HUGO
OMIM
CCDS CCDS72746 CCDS72747
HPRD 04063
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca