Version 5.4
Homo sapiens Protein: PHPT1
Summary
InnateDB Protein IDBP-585685.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PHPT1
Protein Name phosphohistidine phosphatase 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000444757
InnateDB Gene IDBG-92741 (PHPT1)
Protein Structure
UniProt Annotation
Function Exhibits phosphohistidine phosphatase activity.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed abundantly in heart and skeletal muscle.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 12 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0008969 phosphohistidine phosphatase activity
GO:0019855 calcium channel inhibitor activity
GO:0044325 ion channel binding
Biological Process
GO:0006470 protein dephosphorylation
GO:0035971 peptidyl-histidine dephosphorylation
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0051350 negative regulation of lyase activity
GO:2000147 positive regulation of cell motility
GO:2000249 regulation of actin cytoskeleton reorganization
GO:2000984 negative regulation of ATP citrate synthase activity
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR007702 Janus
PFAM PF05005
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NRX4
PhosphoSite PhosphoSite-Q9NRX4
TrEMBL Q9P019
UniProt Splice Variant
Entrez Gene 29085
UniGene
RefSeq
HUGO HGNC:30033
OMIM 610167
CCDS
HPRD 17849
IMGT
EMBL AF161490 AF164795 AF285119 AF393504 AL136644 AL355987 BC024648 BQ922335 CH471090
GenPept AAF29105 AAF80759 AAG01156 AAH24648 AAN52504 CAB66579 CAI12692 CAI12693 EAW88289

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca