Version 5.4
Homo sapiens Gene: PHPT1
Summary
InnateDB Gene IDBG-92741.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PHPT1
Gene Name phosphohistidine phosphatase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000054148
Encoded Proteins
IDBP-92745
phosphohistidine phosphatase 1
IDBP-92751
phosphohistidine phosphatase 1
IDBP-585685
phosphohistidine phosphatase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary PHPT1 is an EDTA-insensitive phosphohistidine phosphatase that catalyzes the dephosphorylation of phosphopeptide I (Ek et al., 2002 [PubMed 12383260]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:136848724-136851043
Strand Forward strand
Band q34.3
Transcripts
ENST00000371661 ENSP00000360724
ENST00000247665 ENSP00000247665
ENST00000492540
ENST00000462205
ENST00000497413
ENST00000463215
ENST00000545326 ENSP00000444757
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 12 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0008969 phosphohistidine phosphatase activity
GO:0019855 calcium channel inhibitor activity
GO:0044325 ion channel binding
Biological Process
GO:0006470 protein dephosphorylation
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0035971 peptidyl-histidine dephosphorylation
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0051350 negative regulation of lyase activity
GO:2000147 positive regulation of cell motility
GO:2000249 regulation of actin cytoskeleton reorganization
GO:2000984 negative regulation of ATP citrate synthase activity
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036504
View Gene Order
ENSBTAG00000021549
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
hsa00051
Fructose and mannose metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001135861 NM_001287342 NM_001287343 NM_014172
HUGO
OMIM
CCDS CCDS48060 CCDS7009
HPRD 17849
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca