Version 5.4
Homo sapiens Protein: UBE2R2
Summary
InnateDB Protein IDBP-58573.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBE2R2
Protein Name ubiquitin-conjugating enzyme E2R 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000263228
InnateDB Gene IDBG-58571 (UBE2R2)
Protein Structure
UniProt Annotation
Function Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination. May be involved in degradation of katenin. {ECO:0000269PubMed:12037680, ECO:0000269PubMed:20061386}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
Experimentally validated
Total 33 [view]
Protein-Protein 33 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005524 ATP binding
GO:0016881 acid-amino acid ligase activity
Biological Process
GO:0006513 protein monoubiquitination
GO:0070936 protein K48-linked ubiquitination
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR000608 Ubiquitin-conjugating enzyme, E2
IPR016135 Ubiquitin-conjugating enzyme/RWD-like
PFAM PF00179
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q712K3
PhosphoSite PhosphoSite-Q712K3
TrEMBL
UniProt Splice Variant
Entrez Gene 54926
UniGene Hs.740452
RefSeq NP_060281
HUGO HGNC:19907
OMIM 612506
CCDS CCDS6546
HPRD 15602
IMGT
EMBL AJ240087 AK000426 AL139113 BC004862 BC047584 CH471071 CR457233
GenPept AAH04862 AAH47584 BAA91156 CAC80336 CAG33514 CAI39656 EAW58479 EAW58480

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca