InnateDB Protein
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IDBP-585839.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLC29A2
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Protein Name
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solute carrier family 29 (nucleoside transporters), member 2
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Synonyms
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DER12; ENT2; HNP36;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000439456
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InnateDB Gene
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IDBG-58944 (SLC29A2)
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Protein Structure
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Function |
Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Very less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine. {ECO:0000269PubMed:9396714}.
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Subcellular Localization |
Basolateral cell membrane {ECO:0000269PubMed:12527552}; Multi-pass membrane protein {ECO:0000269PubMed:12527552}. Nucleus membrane {ECO:0000269PubMed:12527552}; Multi-pass membrane protein {ECO:0000269PubMed:12527552}. Note=Localized at the basolateral cell membrane in polarized MDCK cells.
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Disease Associations |
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Tissue Specificity |
Expressed in skeletal muscle, liver, lung, placenta, brain, heart, kidney and ovarian tissues. {ECO:0000269PubMed:12527552, ECO:0000269PubMed:9396714}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005337
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nucleoside transmembrane transporter activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002259
Equilibrative nucleoside transporter
IPR016196
Major facilitator superfamily domain, general substrate transporter
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PFAM |
PF01733
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PRINTS |
PR01130
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PIRSF |
PIRSF016379
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q14542
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PhosphoSite |
PhosphoSite-Q14542
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
3177
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UniGene |
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RefSeq |
NP_001287797
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HUGO |
HGNC:11004
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OMIM |
602110
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CCDS |
CCDS8137
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HPRD |
03662
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IMGT |
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EMBL |
AF029358
AF034102
AF401235
AK057041
AP001107
BC093634
CH471076
X86681
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GenPept |
AAB97834
AAC39526
AAH93634
AAK92533
BAG51849
CAA60380
EAW74519
EAW74521
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