InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: INSM1

Summary

InnateDB Protein

IDBP-58585.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

INSM1

Protein Name

insulinoma-associated 1

Synonyms

IA-1; IA1;

Species

Homo sapiens

Ensembl Protein

ENSP00000312631

InnateDB Gene

IDBG-58581 (INSM1)

Protein Structure

UniProt Annotation

Function

Sequence-specific DNA-binding transcriptional regulator that plays a key role in neurogenesis and neuroendocrine cell differentiation during embryonic and/or fetal development. Binds to the consensus sequence 5'-[TG][TC][TC][TT][GA]GGG[CG]A-3' in target promoters. Acts as a transcriptional repressor of NEUROD1 and INS expression via its interaction with cyclin CCND1 in a cell cycle-independent manner. Negatively regulates skeletal muscle- specific gene expression in endocrine cells of the pituitary by inhibiting the Notch signaling pathway. Represses target gene transcription by recruiting chromatin-modifying factors, such as HDAC1, HDAC2, HDAC3, KDM1A and RCOR1 histone deacetylases. Binds to its own promoter, suggesting autoregulation as a self-control feedback mechanism. Promotes the generation and expansion of neuronal basal progenitor cells in the developing neocortex. Involved in the differentiation of endocrine cells of the developing anterior pituitary gland, of the pancreas and intestine, and of sympatho-adrenal cells in the peripheral nervous system. Promotes cell cycle signaling arrest and inhibition of cellular proliferation. {ECO:0000269PubMed:11842116, ECO:0000269PubMed:16511571, ECO:0000269PubMed:16569215, ECO:0000269PubMed:18417529, ECO:0000269PubMed:19124461}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in pancreatic duct cells. Expressed in several tumor cell lines of neuroendocrine origin including pheochromocytoma, medullary thyroid carcinoma, insulinoma, medulloblastoma, retinoblastoma, pheochromacytoma, medullary thyroid carcinoma and small cell lung carcinoma. {ECO:0000269PubMed:12890672, ECO:0000269PubMed:1634555}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001047	core promoter binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0030332	cyclin binding
GO:0031490	chromatin DNA binding
GO:0042826	histone deacetylase binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001933	negative regulation of protein phosphorylation
GO:0003309	type B pancreatic cell differentiation
GO:0003310	pancreatic A cell differentiation
GO:0003323	type B pancreatic cell development
GO:0003358	noradrenergic neuron development
GO:0006351	transcription, DNA-templated
GO:0007049	cell cycle
GO:0008285	negative regulation of cell proliferation
GO:0010468	regulation of gene expression
GO:0030154	cell differentiation
GO:0031018	endocrine pancreas development
GO:0035270	endocrine system development
GO:0042421	norepinephrine biosynthetic process
GO:0043254	regulation of protein complex assembly
GO:0045597	positive regulation of cell differentiation
GO:0060290	transdifferentiation
GO:0061104	adrenal chromaffin cell differentiation
GO:0061549	sympathetic ganglion development
GO:0071158	positive regulation of cell cycle arrest
GO:2000179	positive regulation of neural precursor cell proliferation