InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: INSM1

Summary

InnateDB Gene

IDBG-58581.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

INSM1

Gene Name

insulinoma-associated 1

Synonyms

IA-1; IA1

Species

Homo sapiens

Ensembl Gene

ENSG00000173404

Encoded Proteins

IDBP-58585

insulinoma-associated 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:20368121-20370949

Strand

Forward strand

Band

p11.23

Transcripts

ENST00000310227

ENSP00000312631

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001047	core promoter binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0030332	cyclin binding
GO:0031490	chromatin DNA binding
GO:0042826	histone deacetylase binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001933	negative regulation of protein phosphorylation
GO:0003309	type B pancreatic cell differentiation
GO:0003310	pancreatic A cell differentiation
GO:0003323	type B pancreatic cell development
GO:0003358	noradrenergic neuron development
GO:0006351	transcription, DNA-templated
GO:0007049	cell cycle
GO:0008285	negative regulation of cell proliferation
GO:0010468	regulation of gene expression
GO:0030154	cell differentiation
GO:0031018	endocrine pancreas development
GO:0035270	endocrine system development
GO:0042421	norepinephrine biosynthetic process
GO:0043254	regulation of protein complex assembly
GO:0045597	positive regulation of cell differentiation
GO:0060290	transdifferentiation
GO:0061104	adrenal chromaffin cell differentiation
GO:0061549	sympathetic ganglion development
GO:0071158	positive regulation of cell cycle arrest
GO:2000179	positive regulation of neural precursor cell proliferation

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0017053	transcriptional repressor complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000068154

View Gene Order

ENSBTAG00000045526

Not yet available

Pathways

NETPATH

REACTOME

REACT_13650

Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells pathway

REACT_111045

Developmental Biology pathway

REACT_13698

Regulation of beta-cell development pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q01101

TrEMBL

UniProt Splice Variant

Entrez Gene

3642

UniGene

Hs.644967 Hs.89584

RefSeq

NM_002196

HUGO

HGNC:6090

OMIM

600010

CCDS

CCDS13143

HPRD

IMGT

EMBL

AL161658 M93119 U07172

GenPept

AAA20938 AAA58680 CAC36065

RNA Seq Atlas

3642