InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RERG

Summary

InnateDB Protein

IDBP-585855.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RERG

Protein Name

RAS-like, estrogen-regulated, growth inhibitor

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000441505

InnateDB Gene

IDBG-21429 (RERG)

Protein Structure

UniProt Annotation

Function

Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential. {ECO:0000269PubMed:11533059}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11533059}.

Disease Associations

Tissue Specificity

Detected in heart, brain, placenta, lung, liver, skin, kidney and pancreas. Detected in estrogen receptor- positive breast-derived cell lines, but not in estrogen receptor- negative cell lines. Expression is decreased or lost in a significant proportion of primary breast tumors with poor clinical prognosis. {ECO:0000269PubMed:11533059}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005525	GTP binding
GO:0019003	GDP binding
GO:0030331	estrogen receptor binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0008285	negative regulation of cell proliferation
GO:0009725	response to hormone
GO:0015031	protein transport
GO:0030308	negative regulation of cell growth

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005829	cytosol
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001806 Small GTPase superfamily
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00071
PF00025
PF08477

PRINTS

PR00449
PR00328

PIRSF

SMART

SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt