Version 5.4
Homo sapiens Protein: MS4A3
Summary
InnateDB Protein IDBP-586000.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MS4A3
Protein Name membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
Synonyms CD20L; HTM4;
Species Homo sapiens
Ensembl Protein ENSP00000434117
InnateDB Gene IDBG-48835 (MS4A3)
Protein Structure
UniProt Annotation
Function Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin- dependent kinase 2 (CDK2) through its direct binding to cyclin- dependent kinase inhibitor 3 (CDKN3/KAP). {ECO:0000269PubMed:11781350}.
Subcellular Localization Endomembrane system {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Located in the perinuclear area.
Disease Associations
Tissue Specificity Expressed specifically in hematopoietic cells and tissues.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0012505 endomembrane system
GO:0016021 integral component of membrane
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR007237 CD20-like
PFAM PF04103
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96HJ5
PhosphoSite PhosphoSite-Q96HJ5
TrEMBL
UniProt Splice Variant
Entrez Gene 932
UniGene Hs.99960
RefSeq
HUGO HGNC:7317
OMIM 606498
CCDS CCDS31568
HPRD 09403
IMGT
EMBL AP000790 AY095480 AY258289 BC008487 BG494288 L35848
GenPept AAA62319 AAH08487 AAM23312 AAP14648

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca